Safety & Efficacy
Culturelle® Probiotics have been used in clinical studies since 1998. Learn how we differentiate probiotics in the context of quality, efficacy, and safety.
Culturelle® Probiotics are designed for your patients using superior-quality ingredients that have been demonstrated safe and effective in human trials.
Superior Quality Probiotics
Rigorous Quality Control
Culturelle® Probiotics are packaged to ensure the viability of colony-forming units (CFUs) until the end of shelf life without the need for refrigeration.
Higher Standards
Our Probiotics are produced according to Food and Drug Administration (FDA) Regulation 21 CFR Part 111 and manufactured in compliance with FDA's current Good Manufacturing Practice (cGMPα).
Evidence-Based Ingredients
We are proud to deliver microbiome-targeting ingredients that have demonstrated efficacy in human trials, including the #1 clinically-studied probiotic, Lacticaseibacillus rhamnosus GG.
History of our evidence-based formulas
Learn more about our journey to leverage clinical evidence to deliver microbiome-targeted solutions for your patients.
1985
L. rhamnosus GG discovered
Goldin and Gorbach characterize L. rhamnosus GG
1989
Culturelle® Probiotics offers L. rhamnosus GG in a capsule
Adult product delivers shelf-stable L. rhamnosus GG
2009
Culturelle Kids Packets are introduced
A shelf-stable, unflavored L. rhamnosus GG option for children
2010
Culturelle® is the #1 pediatrician recommended probiotic since 2010
Efficacy, safety and accessibility lead to top recommendation by providers
2012
Culturelle® Kids Chewables introduced
Offering a great tasting probiotic for children
2013
Culturelle® Adult Chewables introduced
Adults deserve a great tasting option too
2014
Culturelle® Kids Packets are upgraded
Evidence-based upgrade to contain 5 Billion CFUs
2017
Culturelle® Baby drops and packets are introduced
Delivering the first Culturelle multistrain formula with #1 (L. rhamnosus GG) and #2 (B. lactis, BB-12®) – the most clinically studied strains in children
2018
Culturelle® Women’s Healthy Balance is formulated by women for women
Offering a multistrain formula including a 4-strain lactobacillus blend for vaginal health
2019
Culturelle® Gummies are made available for kids and adults
Clinically studied Bacillus strains in efficacious amounts for children and adults
2019
Culturelle® offers unique Metabolism + Weight Management support for the
Leveraging a select Bifidobacterium and B vitamins, combined with L. rhamnosus GG
2022
Culturelle® Advanced Regularity Probiotic & Prebiotic Fiber offers a sol
Delivers three clinically proven probiotic strains, including L. rhamnosus GG, a two-strain Lactobacillus combination, and a cold-pressed kiwi extract
2022
Culturelle® launches Abdominal Support & Comfort
Combining human milk oligosaccharides and a clinically studied Bacillus strain, Unique IS-2
Partnerships
Clinical
Tufts University
Duke University
Kent State University
University of Nebraska
Massachusetts General Hospital
Virginia Commonwealth
University
McGuire VA Medical Center
Children’s Hospital, Boston
Nemours Children’s Clinic
Children’s Hospital, Philadelphia
Comer Children’s Hospital
Columbia University Medical Center
Johns Hopkins University Medical Center
Texas Children’s Hospital
University of Antwerp
Washington University School of Medicine
Mayo Clinic
Health Advocacy
NEC Society - Building a world without necrotizing enterocolitis (NEC)
National Eczema Association (NEA) - the voice, the resource and the hub for those living with eczema
Canadian Digestive Health Foundation (CDHF) - Canada’s trusted resource on digestive health.
Food Allergy Research & Education (FARE) is a non-profit organization dedicated to food allergy awareness, research, education, and advocacy.
Academy of Nutrition and Dietetics
Educational
American Society for Parenteral and Enteral Nutrition (ASPEN)
AEProBio -creators of the Clinical Guide to Probiotic Products
Council for Responsible Nutrition (CRN)
International Probiotic Association (IPA)
International Scientific Association of Probiotics and Prebiotics (ISAPP)
Are you a healthcare Professional?
The information on this site is intended for healthcare professionals in the United States and is not intended for the general public.