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  • Evidence-Based

Evidence-Based Ingredients

Lacticaseibacillus rhamnosus GG (L. rhamnosus GG)

Formerly known as Lactobacillus rhamnosus GG, Lacticaseibacillus rhamnosus GG is the most extensively studied probiotic strain. In nearly 2000 scientific studies, including over 300 human clinical trials, it has been shown to help restore the balance of the microbiota.* L. rhamnosus GG survives stomach acid and bile, adheres to human intestinal epithelial cells, and produces an antimicrobial substance making this strain an ideal probiotic for support of digestive and immune health.*

Bifidobacterium animalis subsp. lactis BB-12® (Bifidobacterium BB-12®)

Bifidobacterium BB-12® is described in more than 500 scientific publications, out of which more than 200 are publications of clinical studies dating back to 1987. Several clinical studies have shown that Bifidobacterium BB-12®, alone or in combination with other microbiome-targeting ingredients, is associated with an increase in beneficial bacteria and a reduction in potentially pathogenic bacteria.*						

Lactobacillus rhamnosus IMC 501 (Lactobacillus rhamnosus DSM 16104) and Lactobacillus paracasei IMC 502 (Lactobacillus paracasei DSM 16105)

The probiotic combination of two strains, Lactobacillus rhamnosus IMC 501 (Lactobacillus rhamnosus DSM 16104) and Lactobacillus paracasei IMC 502 (Lactobacillus paracasei DSM 16105) has been demonstrated to promote regularity, improve occasional constipation and increase stool volume.* The combination of Lactobacillus rhamnosus IMC 501 and Lactobacillus paracasei IMC 502 gently eases occasional constipation and helps maintain regularity.*						

L. crispatus LbV 88, L. rhamnosus LbV 96, L. jensenii LbV 116, and L. gasseri LbV 150N

The four strain probiotic blend of L. crispatus LbV BB, L. rhamnosus LbV 96, L. jensenii LbV 116, and L. gasseri LbV 150N has been shown to support the vaginal microbiota.* This unique blend — of the most dominant lactobacilli in healthy vaginal microbiota — has been shown to colonize the feminine microbiome after oral administration to help maintain a healthy pH to protect and restore vaginal health.*						

Bifidobacterium animalis subsp. lactis CECT 8145


A randomized, double-blind, placebo-controlled clinical trial demonstrated that consumption of both viable and heat-killed CECT 8145 improved anthropometric adiposity biomarkers including abdominal fat, BMI, and waist circumference, especially in women.* Gut microbiome analyses of participants revealed an increase in Akkermansia spp. in response to CECT 8145. This is notable because Akkermansia has been found to decrease with obesity and metabolic disease.

Bacillus subtilis DE111®

Bacillus subtilis DE111® survives the gastrointestinal tract to reach the intestines to help balance the intestinal microbiota to relieve both occasional diarrhea and occasional constipation by promoting digestive balance.*						

Bacillus coagulans MTCC 5856

Bacillus coagulans MTCC 5856 has been clinically investigated for a variety of health benefits, including the resolution of acute and chronic diarrhea, oral health, and effects in patients with hyperlipidemia.* Through helping to balance the microbiota, Bacillus coagulans MTCC 5856 helps to relieve both occasional diarrhea and constipation to promote digestive health.*						

Kiwi fruit blend

A proprietary kiwi fruit powder, derived from New Zealand green kiwi fruit, has demonstrated prebiotic effects both in vitro and in vivo. This concentrated blend of fresh and freeze dried kiwi fruit has both insoluble and soluble dietary fibers and is considered a “mixed plant cell wall fiber” by the FDA. This prebiotic kiwi fruit powder feeds the good bacteria in the gut microbiome.						

Vitamins B6 and B12

While B vitamins work together to support energy production, each vitamin has a specific role within the body. Through their role as co-enzymes, B6 and B12 participate in a variety of metabolic processes. They also act as antioxidants scavenging dangerous free radicals which, if left unchecked, damage the body through oxidative stress.						

Vitamin B6 (Pyridoxine hydrochloride)

Pyridoxine is converted to pyridoxal phosphate (PLP) within the body. PLP plays important roles in protein, carbohydrate and lipid metabolism to generate energy.						

Vitamin B12 (Cyanocobalamin)

B12 functions primarily as a co-enzyme in intermediary reactions. Vitamin B12 is necessary for forming red blood cells, nerve cells, and bone marrow. B12 supports healthy development, assists in maintaining energy levels, and aids the immune system by facilitating the formation of white blood cells.*						

Vitamin D (Cholecalciferol)

While this nutrient is best known for maintaining bone health due to its role in adequate calcium and phosphate absorption, Vitamin D is also important in the regulation of numerous cellular functions. Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function, and brain cell activity.*						

Omega-3 Long-Chain Polyunsaturated Fatty Acids

As components of the phospholipid bilayer, omega-3 fatty-acids (Omega-3s) play a structural function in cell membranes throughout the human body.* Consumption of Omega-3s has been associated with overall health and the promotion of cardiovascular health.* Omega-3s also play a critical role in maternal and child health.						

Docosahexaenoic acid (DHA)

DHA is a long-chain omega-3 fatty acid that is most concentrated in the brain and eyes. As a structural component of cell membranes, DHA is a critical nutrient for infant development.*						

Eicosapentaenoic acid (EPA)

Like DHA, EPA is a component of cell membranes making it essential for healthy systems throughout the body.*						


lnulin is a naturally occurring dietary fiber found in numerous plants, including onions, artichokes, bananas, and chicory root. Inulin is also a fructan. Like other fructans, it is a prebiotic, meaning that it feeds beneficial microbes in the gut. Colonic bacteria ferment inulin and other prebiotics into short-chain fatty acids which nourish enterocytes.						


Wheat dextrin specifically is a great source of fiber, and more specifically, soluble fiber. It adds bulk to stool helping to balance the intestinal environment and guard against diarrhea and constipation.* As a prebiotic, dextrin has been shown to increase bifidobacteria in the gut microbiota, a genus that has been associated with overall health.*						

Human Milk Oligosaccharides (HMOs)

Unique prebiotics originally found in breast milk and shown to fuel beneficial colonic microbes, specifically bifidobacteria. HMOs increase nutrient production such as short chain fatty acids, protect the gut barrier, and have been shown to inhibit pathogen adhesion and modulate immune response.*